Bone Abstracts

Radiosurgery of the spine is used to treat patients with spinal metastases. Recent studies have shown increased fracture risk in patients treated with high doses of irradiation. This study tested if there is a dose response relationship between prescribed radiation and induced bone loss and metabolism.Methods: Vertebral bodies C5–C7 of ~50 week old female Yucatan minipigs were irradiated at 16, 20, and 24Gy (n=5/dose). The cervical spine re...

Assessment of metaphyseal bone growth in children by peripheral quantitative computed tomography (pQCT) is limited by use of a thin (2.3 mm) 2D slice to represent the ~20 mm metaphyseal region within which there is substantial local variation in bone properties (Marjanovic et al., 2009). In addition, scan positioning is performed by manual visual growth plate identification from which a region located proximal to the growth plate at 4% of tibia leng...

Background: Glucocorticoid immune suppression in kidney transplanted children jeopardizes optimal bone health recovery. So far, there are no studies that evaluate the effect of transplant and corticoid in bone parameters separately.Objective: To determine the effect of early corticosteroid withdrawal in bone parameters.Methods: Randomized, controlled study; two groups: corticosteroid withdrawal (at the 6th day post-transplant, then...